Stimulation of the globus pallidus internus for childhood‐onset dystonia
Identifieur interne : 003720 ( Main/Exploration ); précédent : 003719; suivant : 003721Stimulation of the globus pallidus internus for childhood‐onset dystonia
Auteurs : Giovanna Zorzi [Italie] ; Carlo Marras [Italie] ; Nardo Nardocci [Italie] ; Angelo Franzini [Italie] ; Luisa Chiapparini [Italie] ; Elio Maccagnano [Italie] ; Lucia Angelini [Italie] ; Dario Caldiroli [Italie] ; Giovanni Broggi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2005-09.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Enfant.
English descriptors
- KwdEn :
- Adolescent, Adult, Age of Onset, Antiparkinson Agents (therapeutic use), Child, Child, Preschool, Deep Brain Stimulation (instrumentation), Dystonia, Dystonia (drug therapy), Dystonia (physiopathology), Dystonia (therapy), Female, Globus Pallidus (physiopathology), Humans, Infant, Levodopa (therapeutic use), Male, Nervous system diseases, Questionnaires, Videotape Recording, Walking, childhood dystonia, globus pallidus, status dystonicus, stimulation.
- MESH :
- chemical , therapeutic use : Antiparkinson Agents, Levodopa.
- drug therapy : Dystonia.
- instrumentation : Deep Brain Stimulation.
- physiopathology : Dystonia, Globus Pallidus.
- therapy : Dystonia.
- Adolescent, Adult, Age of Onset, Child, Child, Preschool, Female, Humans, Infant, Male, Questionnaires, Videotape Recording, Walking.
Abstract
We report the results of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 12 patients with childhood‐onset generalized dystonia refractory to medication, including 3 patients with status dystonicus. There were 8 patients who had DYT1‐negative primary dystonia, 1 had DYT1‐positive dystonia, and 3 had symptomatic dystonia. Stimulation was effective in all but 1 patient. Dystonic postures and movements of the axis and limbs responded to DBS to a greater extent than oromandibular dystonia and fixed dystonic postures. These findings provide further evidence that pallidal stimulation is an effective treatment for intractable childhood‐onset dystonia, including status dystonicus, and together with previous findings, suggest that it should be considered the treatment of choice for these conditions. © 2005 Movement Disorder Society
Url:
DOI: 10.1002/mds.20510
Affiliations:
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Chiapparini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroradiology, Istituto Nazionale Neurologico Carlo Besta, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Maccagnano, Elio" sort="Maccagnano, Elio" uniqKey="Maccagnano E" first="Elio" last="Maccagnano">Elio Maccagnano</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuroradiology, Istituto Nazionale Neurologico Carlo Besta, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Angelini, Lucia" sort="Angelini, Lucia" uniqKey="Angelini L" first="Lucia" last="Angelini">Lucia Angelini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Child Neurology, Istituto Nazionale Neurologico Carlo Besta, 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the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2005-09">2005-09</date><biblScope unit="vol">20</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1194">1194</biblScope><biblScope unit="page" to="1200">1200</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D064356E023C4B5AA6AF0B798C9AC26C7CA13EEF</idno><idno type="DOI">10.1002/mds.20510</idno><idno type="ArticleID">MDS20510</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age of Onset</term><term>Antiparkinson Agents (therapeutic use)</term><term>Child</term><term>Child, Preschool</term><term>Deep Brain Stimulation (instrumentation)</term><term>Dystonia</term><term>Dystonia (drug therapy)</term><term>Dystonia (physiopathology)</term><term>Dystonia (therapy)</term><term>Female</term><term>Globus Pallidus (physiopathology)</term><term>Humans</term><term>Infant</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Nervous system diseases</term><term>Questionnaires</term><term>Videotape Recording</term><term>Walking</term><term>childhood dystonia</term><term>globus pallidus</term><term>status dystonicus</term><term>stimulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia</term><term>Globus Pallidus</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Dystonia</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Age of Onset</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Questionnaires</term><term>Videotape Recording</term><term>Walking</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dystonie</term><term>Enfant</term><term>Système nerveux pathologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Enfant</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report the results of deep brain stimulation (DBS) of the globus pallidus internus (GPi) in 12 patients with childhood‐onset generalized dystonia refractory to medication, including 3 patients with status dystonicus. There were 8 patients who had DYT1‐negative primary dystonia, 1 had DYT1‐positive dystonia, and 3 had symptomatic dystonia. Stimulation was effective in all but 1 patient. Dystonic postures and movements of the axis and limbs responded to DBS to a greater extent than oromandibular dystonia and fixed dystonic postures. These findings provide further evidence that pallidal stimulation is an effective treatment for intractable childhood‐onset dystonia, including status dystonicus, and together with previous findings, suggest that it should be considered the treatment of choice for these conditions. © 2005 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Zorzi, Giovanna" sort="Zorzi, Giovanna" uniqKey="Zorzi G" first="Giovanna" last="Zorzi">Giovanna Zorzi</name></noRegion><name sortKey="Angelini, Lucia" sort="Angelini, Lucia" uniqKey="Angelini L" first="Lucia" last="Angelini">Lucia Angelini</name><name sortKey="Broggi, Giovanni" sort="Broggi, Giovanni" uniqKey="Broggi G" first="Giovanni" last="Broggi">Giovanni Broggi</name><name sortKey="Caldiroli, Dario" sort="Caldiroli, Dario" uniqKey="Caldiroli D" first="Dario" last="Caldiroli">Dario Caldiroli</name><name sortKey="Chiapparini, Luisa" sort="Chiapparini, Luisa" uniqKey="Chiapparini L" first="Luisa" last="Chiapparini">Luisa Chiapparini</name><name sortKey="Franzini, Angelo" sort="Franzini, Angelo" uniqKey="Franzini A" first="Angelo" last="Franzini">Angelo Franzini</name><name sortKey="Maccagnano, Elio" sort="Maccagnano, Elio" uniqKey="Maccagnano E" first="Elio" last="Maccagnano">Elio Maccagnano</name><name sortKey="Marras, Carlo" sort="Marras, Carlo" uniqKey="Marras C" first="Carlo" last="Marras">Carlo Marras</name><name sortKey="Nardocci, Nardo" sort="Nardocci, Nardo" uniqKey="Nardocci N" first="Nardo" last="Nardocci">Nardo Nardocci</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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